Friday, February 26, 2016

Tips for staying well

Tips for staying well

Keeping our bodies strong and healthy is one of the most important things we can do for ourselves.

Monday, November 30, 2015

Transplantation 2



Transplantation of human cells, tissues and organs

Global Knowledge Base on Transplantation  (GKT)
Transplantation of human cells, tissues or organs saves many
lives and restores essential functions where no alternatives
of comparable effectiveness exist
In 50 years, transplantation has become a successful worldwide practice. However, there are large differences between countries in access to suitable transplantation and in the level of safety, quality, efficacy of donation and transplantation of human cells, tissues and organs. The ethical aspects of transplantation are at the forefront. In particular, the unmet patients’ needs and the shortage of transplants lead to the temptation of trafficking in human body components for transplantation.

WHO Guiding Principles on Human Cell, Tissue and Organ Transplantation

In 1987 the fortieth World Health Assembly, concerned at the trade for profit in human organs, initiated the preparation of the first WHO Guiding Principles on Transplantation, endorsed by the Assembly in 1991 in resolution WHA44.25. These Guiding Principles have greatly influenced professional codes and practices as well as legislation around the world during almost two decades. After a consultation process that took several years, the Sixty-third World Health Assembly adopted resolution WHA63.22 on 21 May 2010, endorsing the updated WHO Guiding Principles and identifying areas of progress to optimize donation and transplantation practices.

WHA63.22 - Human organ and tissue transplantation

WHO Guiding Principles

The Declaration of Istanbul

Professionals of donation and transplantation from all regions, through many of their organizations and institutions, are endorsing the Declaration of Istanbul on organ trafficking and transplant tourism developed under the leadership of the Transplantation Society and the International Society of Nephrology in May 2008.

Transplantation



Donation and transplantation

Donations from deceased persons should be developed to their maximum therapeutic potential avoiding, whenever possible, the inherent risks to live donors, as stated in WHO Guiding Principle 3. There is a recognized need for communities, and health professionals, to become better educated about donation and transplantation and that is the key to the success of deceased donation programmes.
However, despite the frequent use of materials donated from deceased donors, the donations from living donors are necessary for some types of transplants or to compensate for the limited supply of material available from deceased donors in order to meet patient needs. Living donation is thus practised despite the fact that it involves risks for the donor that may not be negligible.
As the procurement of human material for transplantation from deceased or living donors and the subsequent allogeneic transplantation may entail ethical and safety risks for both the recipient and the donor, strict controls and effective oversight should be carried out by the health authorities to protect them. The Guiding Principles mandate optimal care for donors and recipients.
The transparent oversight of the health authorities over donation and transplantation activities is also essential to increase the trust of the public in the system. In addition, the decision to be a donor is often based on the understanding that a contribution to the availability of transplant resources may someday benefit the health needs of the donor’s family.

If we are prepared to receive a transplant should we need one, then we should be ready to give

Tuesday, November 24, 2015

Laparoscopy and endometriosis

A laparoscopy (keyhole surgery) can be used in the diagnosis or treatment of a number of conditions of the abdomen and pelvic area. The advantage of laparoscopy is that only a small cut (incision) is required. 
The added advantage of laparoscopy in endometriosis is that your diagnosis can be confirmed and treatment can be carried out at the same time. It can also be used to find out where the endometriosis is and how much of it there is, as well as making sure there is no other medical problem that is causing your symptoms.
If endometriosis can be seen during the laparoscopy, a sample will usually be taken for biopsy. This will confirm the diagnosis.
Your treatment will depend on where the endometriosis is found and how much is found.
Spots of endometriosis throughout the pelvis can be removed surgically or by burning (using diathermy or laser). Endometriosis in the ovaries will usually have formed a cyst called an endometriotic cyst (endometrioma). This will need to be removed.
Studies have shown that five years after surgery, up to 70 per cent of women will have no evidence of endometriosis returning.
Not all endometriosis can be treated with laparoscopy, however. Sometimes endometriosis affects other organs such as the bowel or ureter (the tube from the kidney to the bladder). If this is the case, you may require further surgery at a later date. Further surgery is likely to involve other specialist surgeons.

Laser or diathermy?

Laser and diathermy are tools the doctor can use to heat tissue. Both can be used for either burning the endometriosis (ablation) or cutting it out. Both methods have advantages and disadvantages. A gynaecologist will use the method they are most experienced and comfortable with.

Burning or cutting

The Royal Women's Hospital is researching both to find out which is the most effective treatment for endometriosis. In some areas though, cutting it out does seem to be better.

Risks

There are risks with all surgery. With laparoscopy, problems are rare but can be severe. They include:
  • infection in the bladder, uterus or cuts on the abdomen
  • organ damage or bleeding – (one in five hundred)
  • death – (one in twenty thousand).
The specific risks of treating endometriosis with laparoscopy include:
  • damage to bowel (one in three thousand).
  • damage to the bladder or ureter.
These complications may require immediate treatment. They can be serious and may require more extensive surgery at a later time.
Other risks include:
  • the possibility of the symptoms not improving,
  • scar (adhesion) formation.
In some cases it may not be possible to remove all endometriosis or the endometriosis may come back at a later time.
Before surgery your doctor must discuss the risks with you so when you provide consent for the operation you understand what the risks are. Don't be afraid to ask questions.

Treating endometriosis


Endometriosis can be treated medically (with drugs or medicine) or with surgery. Sometimes both medicine and surgery are used. Some women also benefit from alternative therapies.
On this page:

Medications range from pain relief drugs (such as paracetamol and non-steroidal anti-inflammatories) to hormonal treatments that suppress ovulation and menstruation).
Surgery can be used to remove or burn the endometrioses. The most common surgery used is laparoscopy (key-hole surgery).
If the ovaries contain cysts of endometriosis these are best treated surgically as they are unlikely to disappear on their own and they can't be treated with medicine.

Treatment to improve fertility

Surgery has been shown to improve fertility for women with mild endometriosis. Treating more severe endometriosis with surgery, especially if there are cysts in the ovaries, also appears to improve fertility, although this hasn't been fully proven. Medication for endometriois has not been shown to improve fertility.
Other causes of infertility should be looked for and treated.

Treatment for pain

When pain is the main problem, the treatment aims to relieve symptoms and lessen the pain. 
  • Simple pain relievers (paracetamol, etc)
    Many women will experience some relief of symptoms with over-the-counter drugs such as paracetamol (Panadol) and non-steroidal anti-inflammatories (Ponstan, Nurofen, Naprogesic, etc).
  • Hormonal treatments (the Pill, etc)
    Hormone treatments are used to suppress the normal menstrual cycle, which in turn stops or slows endometriosis growth. The simplest way to achieve this is with the Pill. Other hormonal therapies that have been shown to be effective in reducing endometriosis-related pain, are also available. Some women will experience side effects with hormonal treatments.
  • Keyhole surgery or laparoscopy
    May be offered initially to help make the diagnosis. Some women are offered surgery because they don't want to take medicine or because medicines haven't worked. Surgery for endometriosis includes laparoscopy (key-hole surgery), which may be used to make the diagnosis and treat all visible endometriosis. This is done with laser or diathermy, which destroys the endometriosis by burning it. Alternatively the deposits of endometriosis can be cut away.
  • Hysterectomy
    In a small group of women who have severe symptoms that are not relieved by medical or other surgical treatment, more extensive surgery such as hysterectomy and removal of the ovaries may be considered.
  • Bowel surgery
    Sometimes the endometriosis affects the wall of the bowel. When this is causing significant symptoms it may be suggested that the affected piece of bowel is removed. This would require bowel surgery and is uncommon.

Alternative and complementary therapies

There are various treatments available that can either complement your medical treatment or are an alternative to medical treatment. The most popular is traditional Chinese medicine and herbal preparations. Some women experience improvement of their symptoms with these but there is no scientific evidence to support the effectiveness of Chinese medicines in reducing symptoms or improving fertility.
If you use complementary treatments it is wise to discuss their use with your doctor as they may interfere with other prescribed medications. The Pharmaceutical Benefits Scheme (PBS) does not cover the costs of alternative or complementary therapies.

Choosing not to treat endometriosis

Mild endometriosis doesn't always need treatment. You are usually offered treatment to help relieve the symptoms rather that to cure the disease itself.
If left untreated, some endometriosis will improve, but most will stay the same. Some will become more severe without treatment.
For most women with endometriosis, the symptoms will settle once they go through the menopause. Deciding whether or not to treat endometriosis is often a matter of balancing the risks of the treatment against the effect the endometriosis is having on your life.

Benefits and disadvantages of different treatments 

BenefitsDisadvantages
Doing nothing – no treatment
  • No side effects of drugs
  • No risks of surgery
  • Most symptoms continue
  • Some symptoms may get worse
Simple pain relief
(paracetamol, ibuprofen)
  • Easy to get
  • Side effects uncommon
  • Often not effective
  • Ibuprofen use has some health risks
Progesterone-like medications
  • Reduced pain
  • Irregular or no periods
  • Stops endometriosis growth in most cases
  • Some are contraceptive
  • Side effects possible – weight gain, moodiness, acne, increased hair, cramps, breast tenderness
  • Symptoms may recur when treatment is stopped
  • May not fix pain
  • Doesn't improve fertility
  • Shouldn't get pregnant while on drug
  • Not all contraceptive
Menopause-causing medications
  • No periods
  • Reduced pain
  • Stops endometriosis growth in most cases
  • Side effects – hot flushes, sweats
  • Bone thinning if used for more than six months
  • Symptoms may recur when treatment is stopped
  • Shouldn't get pregnant while on drug
  • Not a contraceptive
  • May not fix pain
The combined contraceptive pill
  • Contraceptive
  • Reduced pain
  • Can be taken to reduce or stop periods
  • Side effects – nausea, weight gain
  • Shouldn't get pregnant while on it
  • Small risk of clots in legs or lungs
Laparoscopy
  • A definite diagnosis
  • A long-term cure in up to 70 percent of women
  • No need to use medications long-term
  • Not all endometriosis can be treated this way
  • There are risks assoicated with surgery
  • May not cure the pain
  • Recurrent endometriosis in 30 percent of women
Hysterectomy and removal of endometriosis
  • Achieve long-term cure in over 90 percent of women
  • No need to use medications
  • No more periods
  • Risks of surgery greater than laparoscopy
  • Removes fertility
  • Some women grieve for uterus loss
  • May need HRT if ovaries removed
  • May not cure pain